Fig. 2

Mitotic clock intrinsic rate distribution relationships. Boxplots of mitotic clock age-adjusted intrinsic rate (IR) residuals (from models additionally adjusted for BMI, polyp status, and methylation batch) by aspirin use and colon location for the 10-year follow-up period for EpiTOC (A), EpiTOC2 (B), and MiAge (C). P values are from paired Wilcoxon signed rank tests comparing T2 and T1 for each aspirin use group. T1, timepoint 1 (baseline). T2, timepoint 2 (10-year follow-up)