Fig. 1

A forest plot showing the single-CpG associations of true methylation and hydroxymethylation of NPPA promoter with ischemic stroke. The black squares and line segments illustrate the ORs and 95% CIs of having ischemic stroke associated with DNA methylation and hydroxymethylation levels (after log2-transformation), adjusting for age, sex, education level, current smoking, current drinking, BMI, LDL-C, HDL-C, hypertension, and diabetes. q value indicates the significance level after correction of multiple testing by false discovery rate approach. CI: confidence interval; OR: odds ratio