Fig. 2

Cubic spline curves visualizing the impacts of the average levels of true methylation and hydroxymethylation in the NPPA promoter region on ischemic stroke. Red lines indicate odds ratios (solid) and their 95% confidence intervals (dotted) of ischemic stroke associated with the mean levels of true methylation (a) and hydroxymethylation (b), adjusting for age, sex, education level, current smoking, current drinking, BMI, LDL-C, HDL-C, hypertension, and diabetes. The histogram shows the distribution of participants according to increasing levels of true methylation and hydroxymethylation. CI: confidence interval; OR: odds ratio