Uncovering the significance of CBX3 as an up-and-coming biomarker in cardio-vascular health

Table 1 Epigenetic changes controlled by CBX3 and their relationship with cardiovascular disease

Target	CBX3-mediated epigenetic effect	Effect on CVD	Reference
CD8 + T cells	interaction with chromatin modifiers	cardiovascular disease pro- gression and outcomes	[26]
miR-21	repressed expression	cardiac fibrosis attenuation and remodeling in response to stress	[30]
miR-126	expression regulation	maintenance of vascular in- tegrity and promotion angio- genesis	[31, 32]
Tnnt3, Tbx20, Tbx3, Hand1, PDGFRA	upregulation	cardiac lineage development	[16]
Sox1	downregulation	circulatory system develop- ment	[16]
Wnt4	up-regulation	circulatory system develop- ment	[16]
Cdk8	decreased recruitment	cardiovascular system devel- opment	[33]
CPT1A, ABCG1	negative/positive directions	lipid-associated CpGs	[34]
ABCG1 locus	expression	increased triglyceride levels and a heightened risk of new- onset coronary heart disease	[35, 36]
GATA4	modulation of chromatin environment	cardiac gene regulation	[40]
ApoC3	altered activity	progression of atherosclerosis	[41]

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