Table 2 Immune system regulated by CBX3 and their association with CVD
From: Uncovering the significance of CBX3 as an up-and-coming biomarker in cardio-vascular health
Target/factor | CBX3-mediated mechanism | Effect on CVD | Reference |
|---|---|---|---|
CD8 + effector T cells | increase of LEF-1 and IL-21R | immune response | |
B cells | modulation of the local immune response and structural integrity of blood vessels | progression | [89] |
immune checkpoints and chemokines | immune response modulation | cellular processes and disease states | [92] |
Genes in immune activation and suppression | Interaction | development of atherosclerosis | [92] |
SMURF2 inhibition and TGF-β signaling activation | selective inhibition | stabilization of atherosclerotic plaque | [17] |
NLRP3 inflammasome | prevention of the activation | atherosclerotic lesions | [99] |
IL-1β | reduction of the release | limiting the extent of inflammation and tissue damage | [100] |
inflammatory signals | impedes the vesicular secretion | control of the inflammatory environment | [101] |
CoQ | interaction | macrophage reverse cholesterol transport | |
CX3CL1 | interaction | modulates the inflammatory response within the plaques |